| 货号 | 17594-1mg |
| 描述 | In the renin-angiotensin system, angiotensin I is cleaved by angiotensin-converting enzyme (ACE) to form angiotensin II, which has effects on blood pressure, as well as fluid and electrolyte homeostasis. Angiotensin fragment 1-7 is an angiotensin metabolite that functions as a type 1 angiotensin II receptor agonist whereupon it can control hydroelectrolyte balance and demonstrates vasodilatory and anti-inflammatory actions in opposition to various adverse effects of angiotensin II (Item No. 17150).1 This peptide can be generated by the action of ACE2, a homolog of ACE, on angiotensin II or by the action of neprilysin on angiotensin I.2 It has been studied in the context of ameliorating the symptoms of metabolic syndrome.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Simoes-e-Silva, A.C.,Baracho, N.C.V.,Passaglio, K.T., et al. Renal actions of angiotensin-(1-7). Brazilian Journal of Medical and Biological Research 30(4), 503-513 (1997). 2.Rice, G.I.,Thomas, D.A.,Grant, P.J., et al. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochemistry Journal 383(1), 45-51 (2004). 3.Purushothaman, K.R.,Krishnan, P.,Purushothaman, M., et al. Expression of angiotensin-converting enzyme 2 and its end product angiotensin 1-7 is increased in diabetic atheroma: Implications for inflammation and neovascularization. Cardiovascular Pathology 22, 42-48 (2013). 4.Marcus, Y.,Shefer, G.,Sasson, K., et al. Angiotensin 1-7 as means to prevent the metabolic syndrome: Lessons from the fructose-fed model. Diabetes 62, 1121-1130 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 899 |
| 分子式 | C41H62N12O11 • XC2H4O2 |
| 稳定性 | ≥ 2 years |
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