| 货号 | 16375-5mg |
| 描述 | Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin (Item No. 17161). While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses.1,2,3 Tin protoporphyrin IX (SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM).4,5 It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50s = 35 and 30 nM, respectively).5 SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally.4 It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen.6 SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals.7,8 |
| 别名 | NSC 267099;SnPPIX; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kim, A.N.,Jeon, W.K.,Lee, J.J., et al. Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages. Free Radical Biology & Medicine 49(3), 323-331 (2010). 2.Cable, E.E.,Gildemeister, O.S.,Pepe, J.A., et al. Mechanism of induction of heme oxygenase by metalloporphyrins in primary chick embryo liver cells: Evidence against a stress-mediated response. Molecular and Cellular Biochemistry 169, 13-20 (1997). 3.Surh, Y.J.,Kundu, J.K.,Li, M.H., et al. Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress. Archives of Pharmacal Research 32(8), 1163-1176 (2009). 4.Drummond, G.S. and Kappas, A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proceedings of the National Academy of Sciences of the United States of America 78(10), 6466-6470 (1981). 5.Zakhary, R.,Gaine, S.P.,Dinerman, J.L., et al. Heme oxygenase 2: Endothelial and neuronal localization and role in endothelium-dependent relaxation. Proceedings of the National Academy of Sciences of the United States of America 93(2), 795-798 (1996). 6.Anderson, K.E.,Simionatto, C.S.,Drummond, G.S., et al. Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase. Journal of Pharmacology and Experimental Therapeutics 228(2), 327-333 (1984). 7.Byun, S.J.,Son, Y. and Pae, H.O. Cytoprotective effect of β-lapachone by inducing heme oxygenase-1 expression and AMP-activated protein kinase activation in human endothelial cells. Eur.Rev.Med.Pharmacol.Sci. 18(7), 949-958 (2014). 8.Zhang, M.,Wang, S.,Mao, L., et al. Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1. Journal of Neuroscience 34(5), 1903-1915 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 计算分子量 | 750.3 |
| 分子式 | C34H30Cl2N4O4Sn • 2H |
| CAS号 | 14325-05-4 |
| 稳定性 | ≥ 2 years |
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