| 货号 | 16069-500mg |
| 描述 | Cytarabine is a nucleoside analog that differs from cytosine by the presence of a hydroxyl group at the 2’ position of the sugar residue. It is triphosphorylated in vivo to produce ara-CTP, a competitive inhibitor of DNA polymerases α and β (Kis = 4 and 32 µM, respectively).1,2,3 At low concentrations, ara-CTP is incorporated into DNA, slowing but not stopping DNA synthesis.4 Cytarabine is effective in the treatment of leukemias.4 It can also have antiviral actions on certain types of viruses.5 |
| 别名 | 1-β-D-Arabinofuranosylcytosine;NSC 63878;NSC 287459;U-19920A; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Furth, J.J. and Cohen, S.S. Inhibition of mammalian DNA polymerase by the 5-triphosphate of 1-β-D-arabinofuranosylcytosine and the 5-triphosphate of 9-β-D-arabinofuranoxyladenine. Cancer Research 28(10), 2061-2067 (1968). 2.Graham, F.L. and Whitmore, G.F. Studies in mouse L-cells on the incorporation of 1-β-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-β-D-arabinofuranosylcytosine 5-triphosphate. Cancer Research 30(11), 2636-2644 (1970). 3.Yoshida, S.,Yamada, M. and Masaki, S. Inhibition of DNA polymerase-α and -β of calf thymus by 1-β-D-arabinofuranosylcytosine-5-triphosphate. Biochim.Biophys.Acta. 477(2), 144-150 (1977). 4.Pourquier, P.,Takebayashi, Y.,Urasaki, Y., et al. Induction of topoisomerase I cleavage complexes by 1-β-D-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells. Proceedings of the National Academy of Sciences of the United States of America 97(4), 1885-1890 (2000). 5.Volmer, R.,Bajramovic, J.J.,Schneider, U., et al. Mechanism of the antiviral action of 1-β-D-arabinofuranosylcytosine on Borna disease virus. Journal of Virology 79(7), 4514-4518 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 243.2 |
| 分子式 | C9H13N3O5 |
| CAS号 | 147-94-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |