| 货号 | 15936-1mg |
| 描述 | Volinanserin is a potent and selective antagonist of the serotonin receptor 5-HT2A(Ki = 0.36-0.85 nM).1,2 It weakly binds 5-HT2C, α1-adrenergic, and sigma receptors (Ki = 88, 128, and 87 nM) and much less effectively associates with other serotonin, dopamine, adrenergic, muscarinic acetylcholine receptors and monoamine transporters.2,3 Volinanserin displays antipsychotic activity, attenuates impulsivity, and augments antidepressant effects in vivo.1,4,5 |
| 别名 | MDL 100907; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Sorensen, S.M.,Kehne, J.H.,Fadayel, G.M., et al. Characterization of the 5-HT2 receptor antagonist MDL 100907 as a putative atypical antipsychotic: Behavioral, electrophysiological and neurochemical studies. Journal of Pharmacology and Experimental Therapeutics 266(2), 684-691 (1993). 2.Kehne, J.H.,Baron, B.M.,Carr, A.A., et al. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. Journal of Pharmacology and Experimental Therapeutics 277(2), 968-981 (1996). 3.Pehek, E.A.,Nocjar, C.,Roth, B.L., et al. Evidence for the preferential involvement of 5-HT2A serotonin receptors in stress- and drug-induced dopamine release in the rat medial prefrontal cortex. Neuropsychopharmacology 31(2), 265-277 (2006). 4.Ardayfio, P.A.,Benvenga, M.J.,Chaney, S.F., et al. The 5-hydroxytryptamine2A receptor antagonist R-(+)-α-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat. Journal of Pharmacology and Experimental Therapeutics 327(3), 891-897 (2008). 5.Boothman, L.J.,Mitchell, S.N. and Sharp, T. Investigation of the SSRI augmentation properties of 5-HT2 receptor antagonists using in vivo microdialysis. Neuropharmacology 50(6), 726-732 (2006). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 373.5 |
| 分子式 | C22H28FNO3 |
| CAS号 | 139290-65-6 |
| 稳定性 | ≥ 2 years |
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