CID755673
货号：
15924-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 15924-1mg |
| 描述 | Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.1 The three human PKD isoforms target a variety of proteins to alter cell proliferation, survival, invasion, and protein transport. CID755673 is a small molecule inhibitor of PKD (IC50s = 182, 280, 227 nM for PKD1, 2, and 3, respectively) that exhibits higher selectivity for PKD over Akt, polo-like kinase 1, CDK activating kinase, CAMKII and three different PKC isoforms (IC50s range from 15 to > 50 µM).2 At 25 µM, CID755673 has been shown to inhibit prostate cancer cell proliferation, cell migration, and invasion.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rozengurt, E.,Rey, O. and Waldron, R.T. Protein kinase D signaling. The Journal of Biological Chemisty 280(14), 13205-13208 (2005).
2.Sharlow, E.R.,Giridhar, K.V.,LaValle, C.R., et al. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. The Journal of Biological Chemisty 283(48), 33516-33526 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 217.2 |
| 分子式 | C12H11NO3 |
| CAS号 | 521937-07-5 |
| 稳定性 | ≥ 2 years |
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