| 货号 | 15632-5mg |
| 描述 | SN-38 is the active metabolite of irinotecan (Item No. 14180), a derivative of the alkaloid camptothecin (Item No. 11694), and acts as a potent inhibitor of DNA topoisomerase I.1,2 It is formed by the hydrolysis of irinotecan by carboxylesterases and metabolized through glucuronidation by UDP glucuronosyl transferase 1A1.3,4 SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC50 = 8.8 nM) compared to irinotecan (IC50 > 100 nM).1,2 |
| 别名 | 7-Ethyl-10-Hydroxycamptothecin;7-ethyl-10-hydroxy-20(S)-Camptothecin;NK 012; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rothenberg, M.L. Topoisomerase I inhibitors: Review and update. Annals of Oncology 8(9), 837-855 (1997). 2.Dancey, J. and Eisenhauer, E.A. Current perspectives on camptothecins in cancer treatment. Br. J. Cancer 74(3), 327-338 (1996). 3.Mathijssen, R.H.J.,van Alphen, R.J.,Verweij, J., et al. Clinical pharmacokinetics and metabolism of irinotecan (CPT-11). Clin. Cancer Res. 7(8), 2182-2194 (2001). 4.Ma, M.K. and McLeod, H.L. Lessons learned from the irinotecan metabolic pathway. Curr. Med. Chem. 10(1), 41-49 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 392.4 |
| 分子式 | C22H20N2O5 |
| CAS号 | 86639-52-3 |
| 稳定性 | ≥ 2 years |
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