| 货号 | 14843-25g |
| 描述 | Busulfan is an alkyl sulfonate that acts as an alkylating antineoplastic agent.1 It forms both intra- and interstrand crosslinks on DNA.2,3 In mammals, busulfan causes profound and prolonged reduction in the generation of hematopoietic progenitors without significantly affecting lymphocyte levels or humoral antibody responses.4 |
| 别名 | Busulphan;Mielosan;Milecitan;Myeloleukon;Mylecytan;Myleran;NCI C01592;NSC 750; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Appelbaum, F.R. Optimizing the conditioning regimen for acute myeloid leukemia. Best Pract.Res.Clin.Haematol. 22(4), 543-550 (2009). 2.Iwamoto, T.,Hiraku, Y.,Oikawa, S., et al. DNA intrastrand cross-link at the 5-GA-3 sequence formed by busulfan and its role in the cytotoxic effect. Cancer Science 95, 454-458 (2004). 3.Ponti, M.,Souhami, R.L.,Fox, B.W., et al. DNA interstrand crosslinking and sequence selectivity of dimethanesulphonates. British Journal of Cancer 63(5), 743-747 (1991). 4.Copelan, E.A. and Deeg, H.J. Conditioning for allogeneic marrow transplantation in patients with lymphohematopoietic malignancies without the use of total body irradiation. Blood 80(7), 1648-1658 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 246.3 |
| 分子式 | C6H14O6S2 |
| CAS号 | 55-98-1 |
| 稳定性 | ≥ 2 years |
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