Canagliflozin
货号：
11575-5mg 基本售价：
546.0 元 规格：
5 mg
产品信息
概述| 货号 | 11575-5mg |
| 描述 | Canagliflozin is an inhibitor of sodium-glucose cotransporter 2 (SGLT2; IC50 = 2.2 nM) that less potently blocks SGLT1 (IC50 = 910 nM).1 Canagliflozin is orally bioavailable and lowers plasma glucose by lowering the renal threshold for glucose and increasing urinary glucose excretion in animals.1,2 Formulations containing SGLT2 inhibitors, including canagliflozin, are used to treat type 2 diabetes mellitus.3 |
| 别名 | JNJ-24831754;TA-7284; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nomura, S.,Sakamaki, S.,Hongu, M., et al. Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus. Journal of Medicinal Chemistry 53, 6355-6360 (2010).
2.Sha, S.,Devineni, D.,Ghosh, A., et al. Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects. Diabetes Obes. Metab. 13(7), 669-672 (2011).
3.Reed, J.W. Impact of sodium-glucose cotransporter 2 inhibitors on blood pressure. Vasc. Health Risk Manag. 2016, 393-405 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 444.5 |
| 分子式 | C24H25FO5S |
| CAS号 | 842133-18-0 |
| 稳定性 | ≥ 2 years |
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