24(R)-hydroxy Cholesterol
货号：
10217-1mg 基本售价：
546.0 元 规格：
1 mg
产品信息
概述| 货号 | 10217-1mg |
| 描述 | 24(S)-hydroxy Cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis.1 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRα and LXRβ nuclear receptors with slightly reduced potency (EC50 = 7 and 4 μM, respectively) compared to the natural isomer (EC50 = 4 and 3 μM, respectively).1,2 |
| 别名 | 24-Epicerebrosterol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vaya, J., and Schipper, H.M. Oxysterols, cholesterol homeostasis, and Alzheimer disease. Journal of Neurochemistry 102, 1727-1737 (2007).
2.Janowski, B.A.,Grogan, M.J.,Jones, S.A., et al. Structural requirements of ligands for the oxysterol liver X receptors LXRα and LXRβ. Proceedings of the National Academy of Sciences of the United States of America 96(1), 266-271 (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 402.7 |
| 分子式 | C27H46O2 |
| CAS号 | 27460-26-0 |
| 稳定性 | ≥ 2 years |
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