CK 869
货号：
15251-1mg 基本售价：
532.0 元 规格：
1 mg
产品信息
概述| 货号 | 15251-1mg |
| 描述 | CK 869 is an inhibitor of actin polymerization via inhibition of the actin-related protein 2/3 (Arp2/3) complex, leading to reduced cell motility rate and rearrangement of F-actin in M-1 cells.1 It inhibits comet tail formation by L. monocytogenes with an IC50 value of 7 µM.2 It also impairs cell adhesion and cell spreading in MCF10A human breast epithelial cells.3 |
| 别名 | CK 0157869; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ilatovskaya, D.V.,Chubinskiy-Nadexhdin, V.,Pavlov, T.S., et al. Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly. Cell Tissue Res. 354(3), 783-792 (2013).
2.Nolen, B.J.,Tomasevic, N.,Russell, A., et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460(7258), 1031-1034 (2009).
3.Beckham, Y.,Vasquez, R.J.,Stricker, J., et al. Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly. PLOS one 9(6), e100943 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 394.3 |
| 分子式 | C17H16BrNO3S |
| CAS号 | 388592-44-7 |
| 稳定性 | ≥ 2 years |
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