Gö 6976
货号：
13310-500ug 基本售价：
504.0 元 规格：
500 ug
产品信息
概述| 货号 | 13310-500ug |
| 描述 | Gö 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively.1 It does not inhibit the activity of PKCδ, PKCε, or PKCζ (IC50s > 3 μM), indicating a preference for the Ca2+-dependent subtypes, PKCα and PKCβ1.1 Gö 6976 also inhibits the checkpoint kinases Chk1/2.2 It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.2,3 |
| 别名 | PD 406976; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martiny-Baron, G.,Kazanietz, M.G.,Mischak, H., et al. Selective inhibition of protein kinase C isoenzymes by the indolocarbazole Gö 6976. The Journal of Biological Chemisty 268, 9194-9197 (1993).
2.Kohn, E.A.,Yoo, C.J., and Eastman, A. The protein kinase C inhibitor Gö6976 is a potent inhibitor of DNA damage-induced S and G2 cell cycle checkpoints. Cancer Research 63, 31-35 (2003).
3.Kawabe, T. G2 checkpoint abrogators as anticancer drugs. Molecular Cancer Therapeutics 3(4), 513-519 (2004).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 378.4 |
| 分子式 | C24H18N4O |
| CAS号 | 136194-77-9 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
