T-2 Toxin
货号：
11444-1mg 基本售价：
504.0 元 规格：
1 mg
产品信息
概述| 货号 | 11444-1mg |
| 描述 | T-2 toxin is a common trichothecene mycotoxin produced by Fusarium species, which can infect grain crops causing alimentary toxic aleukia in humans and animals. It triggers a ribotoxic response through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs, interferes with the metabolism of membrane phospholipids, and increases liver lipid peroxides.1 T-2 toxin is highly cytotoxic to macrophages, inducing apoptosis in primary porcine alveolar macrophage cells with an IC50 value of 19.47 nM. At 3 nM it decreases the production of inflammatory mediators (IL-1β, TNFα, and nitric oxide), TLR4, and TLR2/6 agonists.2 |
| 别名 | Fusariotoxin T-2;Insariotoxin;Mycotoxin T-2;NSC 138780; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Doi, K. and Uetsuka, K. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. International Journal of Molecular Sciences 12, 5213-5237 (2011).
2.Seeboth, J.,Solinhac, R.,Oswald, I.P., et al. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig. Veterinary Research 43, 1-18 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 466.6 |
| 分子式 | C24H34O9 |
| CAS号 | 21259-20-1 |
| 稳定性 | ≥ 2 years |
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