MK-1775
货号：
21266-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 21266-5mg |
| 描述 | MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM).1 It has been shown to inhibit the phosphorylation of Cdc2 at tryosine-15, which abrogates the G2 DNA damage checkpoint.1 In p53-deficient tumors that rely solely on the G2 checkpoint upon DNA damage, MK-1775, in combination with DNA-damaging chemotherapeutic agents, is reported to induce apoptosis in vitro and potentiate the inhibition of tumor growth in vivo.1 |
| 别名 | AZD 1775; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hirai, H.,Iwasawa, Y.,Okada, M., et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol. Cancer Ther. 8(11), 2992-3000 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 500.6 |
| 分子式 | C27H32N8O2 |
| CAS号 | 955365-80-7 |
| 稳定性 | ≥ 2 years |
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