KT109
货号：
18933-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18933-1mg |
| 描述 | In humans, two forms of diacylglycerol lipase, DAGLα and DAGLβ, generate the endocannabinoid 2-arachidonoyl glycerol (2-AG; Item No. 62160) by attacking DAG at the sn-1 position. KT109 is a selective inhibitor of DAGLβ with an IC50 value of 42 nM.1 It demonstrates ~60-fold selectivity for DAGLβ over DAGLα, and negligible activity against other key enzymes involved in endocannabinoid signaling, including FAAH, MAGL, and ABHD11.1 KT109 has been shown to disrupt the lipid network involved in macrophage inflammatory responses, lowering 2-AG, as well as arachidonic acid (Item No. 90010) and eicosanoids, in mouse peritoneal macrophages.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hsu, K.L.,Tsuboi, K.,Adibekian, A., et al. DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nature Chemical Biology 8(12), 999-1007 (2012).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 422.5 |
| 分子式 | C27H26N4O |
| CAS号 | 1402612-55-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
