CEP-28122
货号：
18406-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 18406-1mg |
| 描述 | CEP-28122 is a potent inhibitor of anaplastic lymphoma kinase (ALK; IC50 = 1.9 nM) that less potently inhibits other tyrosine and serine/threonine kinases.1 It blocks the phosphorylation of ALK and other ALK substrates in cells and induces concentration-dependent growth inhibition or cytotoxicity of ALK-positive cancer cells.1 CEP-28122 is orally active, inhibiting ALK tyrosine phosphorylation in tumor xenografts in mice for more than 12 hours following single oral dosing at 30 mg/kg.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chang, M.,Quail, M.R.,Gingrich, D.E., et al. CEP-28122, a highly potent and selective orally active inhibitor of anaplastic lymphoma kinase with antitumor activity in experimental models of human cancers. Molecular Cancer Therapeutics 11(3), 670-679 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 539.1 |
| 分子式 | C28H35ClN6O3 |
| CAS号 | 1022958-60-6 |
| 稳定性 | ≥ 2 years |
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