YS-035 (hydrochloride)
货号：
17705-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 17705-5mg |
| 描述 | YS-035 is a verapamil derivative that dose-dependently blocks calcium uptake viaNa+/Ca2+ exchange in diverse types of cells (Ki = 28 µM).1 It inhibits calcium uptake by muscle cells, brain synaptosomes, and kidney fibroblasts.1 YS-035 also prevents calcium release from mitochondria induced by Ruthenium Red but not by uncouplers, respiratory inhibitors, or a chelating agent.1 YS-035 is used to characterize the role of calcium currents in smooth muscle and neuronal electrophysiology.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Deana, R.,Panato, L.,Cancellotti, F.M., et al. Properties of a new calcium ion antagonist on cellular uptake and mitochondrial efflux of calcium ions. Biochemistry Journal 218, 899-905 (1984).
2.Kammer, T.,Berger, F.,Borchard, U., et al. Electrophysiological characterization of class III activity of a verapamil derivative in guinea-pig cardiac tissues. Arzneimittel-Forschung 43(3), 302-308 (1993).
3.Mironov, S.L.,Langohr, K., and Richter, D.W. Hyperpolarization-activated current, Ih, in inspiratory brainstem neurons and its inhibition by hypoxia. European Journal of Neuroscience 12(2), 520-526 (2000).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 395.9 |
| 分子式 | C21H29NO4 • HCl |
| CAS号 | 89805-39-0 |
| 稳定性 | ≥ 2 years |
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