ZM 39923 (hydrochloride)
货号：
16729-1mg 基本售价：
490.0 元 规格：
1 mg
产品信息
概述| 货号 | 16729-1mg |
| 描述 | Janus kinases (JAKs) are non-receptor kinases that mediate signaling through cytokine receptors, often to members of the signal transducer and activator of transcription (Stat) family.1 ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively).2 In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the transglutaminase Factor XIIIa (IC50s= 10 and 25 nM, respectively).3 It breaks down in neutral buffer to form ZM 449829, which is also an inhibitor of JAK3, TGM2, and Factor XIIIa.2,3 |
| 别名 | JAK3 Inhibitor IV; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yamaoka, K.,Saharinen, P.,Pesu, M., et al. The janus kinases (Jaks). Genome Biology 5(12), 1-6 (2004).
2.Brown, G.R.,Bamford, A.M.,Bowyer, J., et al. Naphthyl ketones: A new class of Janus kinase 3 inhibitors. Bioorganic & Medicinal Chemistry Letters 10(6), 575-579 (2000).
3.Lai, T.S.,Liu, Y.,Tucker, T., et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chemistry & Biology 15(9), 969-978 (2008).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 367.9 |
| 分子式 | C23H25NO • HCl |
| CAS号 | 1021868-92-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
