| 货号 | 16409-500mg |
| 描述 | Carprofen is a non-steroidal anti-inflammatory drug (NSAID) commonly used in animals to combat pain and inflammation, particularly as associated with osteoarthritis.1,2 Like many NSAIDs, carprofen inhibits both cyclooxygenases COX-1 and COX-2 (IC50s = 22.3 and 3.9 µM, respectively).3,4 It also inhibits fatty acid amide hydrolase (IC50 = 74 µM), blocking the metabolism of the cannabinoid receptor ligand, arachidonoyl ethanolamide (Item No. 90050).4,5 |
| 别名 | Carprodyl;NSC 297935; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Malek, S.,Sample, S.J.,Schwartz, Z., et al. Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis. BMC Vet.Res. 8, 1-17 (2012). 2.Brown, D.C.,Boston, R.C.,Coyne, J.C., et al. Ability of the canine brief pain inventory to detect response to treatment in dogs with osteoarthritis. Journal of the American Veterinary Medical Association 233(8), 1278-1283 (2008). 3.Li, J.,Lynch, M.P.,DeMello, K.L., et al. In vitro and in vivo profile of 2-(3-di-fluoromethyl-5-phenylpyrazol-1-yl)-5-methanesulfonylpyride, a potent, selective, and orally active canine COX-2 inhibitor. Bioorganic & Medicinal Chemistry Letters 15, 1805-1809 (2005). 4.Favia, A.D.,Habrant, D.,Scarpelli, R., et al. Identification and characterization of carprofen as a multi-target FAAH/COX inhibitor. Journal of Medicinal Chemistry 55(20), 8807-8826 (2012). 5.Bertolacci, L.,Romeo, E.,Veronesi, M., et al. A binding site for nonsteroidal anti-inflammatory drugs in fatty acid amide hydrolase. Journal of the American Chemical Society 135(1), 22-25 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 273.7 |
| 分子式 | C15H12ClNO2 |
| CAS号 | 53716-49-7 |
| 稳定性 | ≥ 2 years |
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