| 货号 | 16377-5mg |
| 描述 | MPTP is a neurotoxin used to cause selective destruction of dopaminergic neurons in animal models of parkinsonism.1,2,3,4 MPTP is metabolized by monoamine oxidase B to produce MPDP+ and MPP+, with MP+ being the active toxic agent.5MPP+ induces neurotoxicity primarily by inhibiting complex I of the mitochondrial electron transport chain, resulting in ATP depletion and increased oxidative stress.5 The key features of different neurotoxic models of Parkinson’s disease, including the MPTP model, have been detailed.5 |
| 别名 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine;NSC 139654; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burns, R.S.,Chiueh, C.C.,Markey, S.P., et al. A primate model of parkinsonism: Selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proceedings of the National Academy of Sciences of the United States of America 80(14), 4546-4550 (1983). 2.Fritz, R.R.,Abell, C.W.,Patel, N.T., et al. Metabolism of the neurotoxin in MPTP by human liver monoamine oxidase B. FEBS Letters 186(2), 224-228 (1985). 3.Javitch, J.A.,DAmato, R.J.,Strittmatter, S.M., et al. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: Uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proceedings of the National Academy of Sciences of the United States of America 82(7), 2173-2177 (1985). 4.Goshima, Y.,Misu, Y.,Arai, N., et al. Nanomolar L-dopa facilitates release of dopamine via presynaptic β-adrenoceptors: Comparative studies on the actions in striatal slices from control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated C57 black mice, an animal model for Parkinson’s disease. Japanese Journal of Pharmacology 55(1), 93-100 (1991). 5.Tieu, K. A guide to neurotoxic animal models of Parkinson’s disease. Cold Spring Harb.Perspect.Med. 1(1), (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥95% |
| 计算分子量 | 209.7 |
| 分子式 | C12H15N • HCl |
| CAS号 | 23007-85-4 |
| 稳定性 | ≥ 2 years |
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