| 货号 | 16209-1mg |
| 描述 | Pifithrin-α (Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.1p-nitro-Pifithrin-α is a cell-permeable analog of pifithrin-α.2 It blocks p53-mediated expression of p21/WAF1 and apoptosis in cortical neurons ten-fold more potently than pifithrin-α.2p-nitro-Pifithrin-α, at 10 µM, suppresses p53-mediated TGF-β1 expression in human proximal tubular cells and attenuates steatosis and liver injury in mice fed a high-fat diet.3,4 It is slowly converted into a more potent cyclized form, p-nitro cyclic pifithrin-α, when incubated in biological media (t½ = 8 h).2 |
| 别名 | p-nitro-PFT-α; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Komarov, P.G.,Komarova, E.A.,Kondratov, R.V., et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 285, 1733-1737 (1999). 2.Pietrancosta, N.,Moumen, A.,Dono, R., et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: Discovery of a highly potent in vivo inhibitor and its action mechanism. Journal of Medicinal Chemistry 49(12), 3645-3652 (2006). 3.Shimizu, H.,Yisireyili, M.,Nishijima, F., et al. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. Am.J.Nephrol. 37(2), 97-103 (2013). 4.Derdak, Z.,Villegas, K.A.,Harb, R., et al. Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease. Journal of Hepatology 58(4), 785-791 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 398.3 |
| 分子式 | C15H15N3O3S • HBr |
| CAS号 | 389850-21-9 |
| 稳定性 | ≥ 2 years |
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