PNU-120596
货号：
14304-5mg 基本售价：
490.0 元 规格：
5 mg
产品信息
概述| 货号 | 14304-5mg |
| 描述 | PNU-120596 is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor (nAChR), increasing agonist-evoked calcium flux (EC50 = 216 nM).1 It has no detectable effect on α4β2, α3β4, or α9β10 nAChRs. PNU-120596 increases the frequency of ACh-evoked GABAergic postsynaptic currents in rat hippocampal slices and improves the auditory gating deficit caused by amphetamine in rats.1,2 It also reduces the cortical/subcortical infarct volume caused by transient focal cerebral ischemia in rats.3 |
| 别名 | NSC 216666; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hurst, R.S.,Hajos, M.,Raggenbass, M., et al. A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: In vitro and in vivo characterization. Journal of Neuroscience 25(17), 4396-4405 (2015).
2.Timmermann, D.B.,Gronlien, J.H.,Kohlhaas, K.L., et al. An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. JPET 323(1), 294-307 (2007).
3.Kalappa, B.I.,Sun, F.,Johnson, S.R., et al. A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischaemia. Brit.J.Pharmacol. 169, 1862-1878 (2013).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 311.7 |
| 分子式 | C13H14ClN3O4 |
| CAS号 | 501925-31-1 |
| 稳定性 | ≥ 2 years |
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