Thyroid Hormone Receptor Antagonist (1-850)
货号：
17248-1mg 基本售价：
476.0 元 规格：
1 mg
产品信息
概述| 货号 | 17248-1mg |
| 描述 | The activity of the thyroid hormones, L-thyroxine (T4; Item No. 14116) and 3,3,5-triiodo-L-thyronine (T3; Item No. 16028), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary.1 Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 µM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3.2 This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.OShea, P.J. and Williams, G.R. Insight into the physiological actions of thyroid hormone receptors from genetically modified mice. Journal of Endocrinology 175(3), 553-570 (2002).
2.Schapira, M.,Raaka, B.M.,Das, S., et al. Discovery of diverse thyroid hormone receptor antagonists by high-throughput docking. Proceedings of the National Academy of Sciences of the United States of America 100(12), 7354-7359 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 463.4 |
| 分子式 | C21H20F3N5O4 |
| CAS号 | 251310-57-3 |
| 稳定性 | ≥ 2 years |
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