| 货号 | 15593-25mg |
| 描述 | 5-Deoxy-5-methylthioadenosine (MTA) is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine.1 This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively).2 At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.3,1,4,5 |
| 别名 | Methylthioadenosine;MTA;NSC 335422;Vitamin L2; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Huang, S. Histone methyltransferases, diet nutrients and tumour suppressors. Nature Reviews.Cancer 2(6), 469-476 (2002). 2.Kehraus, S.,Gorzalka, S.,Hallmen, C., et al. Novel amino acid derived natural products from the ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivative. Journal of Medicinal Chemistry 47(9), 2243-2255 (2004). 3.Oliva, A.,Galletti, P.,Zappia, V., et al. Studies on substrate specificity of S-adenosylmethionine: Protein-carboxyl methyltransferase from calf brain. European Journal of Biochemistry 104(2), 595-602 (1980). 4.Cole, P.A. Chemical probes for histone-modifying enzymes. Nature Chemical Biology 4(10), 590-597 (2008). 5.Lee, S.H. and Cho, Y.D. Induction of apoptosis in leukemia U937 cells by 5-deoxy-5-methylthioadenosine, a potent inhibitor of protein carboxylmethyltransferase. Experimental Cell Research 240(2), 282-292 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 297.3 |
| 分子式 | C11H15N5O3S |
| CAS号 | 2457-80-9 |
| 稳定性 | ≥ 1 year |
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