| 货号 | 63330-250ug |
| 描述 | Geranylgeranyl pyrophosphate is an intermediate in the HMG-CoA reductase pathway derived directly from farnesyl pyrophosphate and used in the biosynthesis of terpenes and terpenoids.1 It is also serves as a substrate in the prenylation of a variety of critical intracellular proteins including small GTPases.2 This post-translational modification is necessary for correct localization of proteins to intracellular membranes for proper functionality and has become a focus of anticancer drug discovery.3,4 |
| 别名 | GGPP; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vance, D.E. Cholesterol and related derivatives. Biochemistry 2nd ed., 725-748 (1988). 2.McTaggart, S.J. Isoprenylated proteins. Cell Mol.Life Sci. 63(3), 255-267 (2006). 3.Baron, R.A. and Seabra, M.C. Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate. Biochemistry Journal 415(1), 67-75 (2008). 4.Maynor, M.,Scott, S.A.,Rickert, E.L., et al. Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs. Bioorganic & Medicinal Chemistry Letters 18(6), 1889-1892 (2008). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 501.5 |
| 分子式 | C20H33O7P2 • 3NH4 |
| CAS号 | 313263-08-0 |
| 稳定性 | ≥ 1 year |
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