| 货号 | 19686-1g |
| 描述 | Cetirizine is a bioactive carboxylated metabolite of hydroxyzine that acts as a selective histamine H1 receptor antagonist (pKi = 8).1 As a second generation antihistamine, it is non-sedating due to low lipophilicity, which prevents blood-brain barrier transit.2 Cetirizine is a racemic mixture composed of equal amounts of two enantiomers, R-levocetirizine and S-dextrocetirizine, with pharmacological activity residing primarily in the (R)-isomer.3 Cetirizine has also been shown to inhibit eosinophil chemotaxis and leukotriene B4 release independent from H1antagonism.4 |
| 别名 | UCB-P 071; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Thurmond, R.L.,Gelfand, E.W. and Dunford, P.J. The role of histamine H1 and H4 receptors in allergic inflammation: The search for new antihistamines. Nature Reviews.Drug Discovery 7, 41-53 (2008). 2.Tillement, J.P. The advantages for an H1 antihistamine of a low volume of distribution. Allergy 55(suppl 60), 17-21 (2000). 3.Zhang, L.,Cheng, L. and Hong, J. The clinical use of cetirizine in the treatment of allergic rhinitis. Pharmacology 92(1-2), 14-25 (2013). 4.Köller, M.,Hilger, R.A.,Rihoux, J.P., et al. Cetirizine exerts anti-inflammatory effects on human neutrophils. International Archives of Allergy and Immunology 110(1), 52-56 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 461.8 |
| 分子式 | C21H25ClN2O3 • 2HCl |
| CAS号 | 83881-52-1 |
| 稳定性 | ≥ 2 years |
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