VU0359595
货号：
10955-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 10955-1mg |
| 描述 | Phospholipase D (PLD) is an enzyme that cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1, and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. VU0359595 is an inhibitor of PLD1(IC50 = 3.7 nM) that is >1,700-fold selective over PLD2(IC50 = 6.4 μM).1 Preliminary evidence suggests that VU0359595 does not interact with the catalytic site of PLD, but instead may bind and inhibit PLD through an allosteric site.1 |
| 别名 | CID-53361951;ML-270; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Lewis, J.A.,Scott, S.A.,Lavieri, R., et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorganic & Medicinal Chemistry Letters 19(7), 1916-1920 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 497.4 |
| 分子式 | C25H29BrN4O2 |
| CAS号 | 1246303-14-9 |
| 稳定性 | ≥ 2 years |
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