BEC
货号：
10170-1mg 基本售价：
406.0 元 规格：
1 mg
产品信息
概述| 货号 | 10170-1mg |
| 描述 | L-Arginine serves as a common substrate for both nitric oxide synthase (NOS) and arginase in the cell. NOS catalyzes the oxidation of arginine to citrulline and NO with Nω-hydroxy-L-arginine (NOHA) formed as an intermediate. Arginase, on the other hand, catalyzes the hydrolysis of arginine into urea and L-ornithine. BEC is a potent slow-binding competitive inhibitor of recombinant rat liver arginase I with a Ki of 0.4-0.6 µM.1 It is also a potent inhibitor of human arginase II with Ki values of 0.31 µM and 30 nM at pH 7.5 and 9.5, respectively.2 It does not inhibit murine iNOS at concentrations up to 1 mM. BEC significantly enhances NO-dependent relaxation of human penile corpus canvernosum smooth muscle in vitro at concentrations between 0.1-1.0 mM.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, N.N.,Cox, J.D.,Baggio, R.F., et al. Probing erectile function: S-(2-boronoethyl)-L-cysteine binds to arginase as a transition state analogue and enhances smooth muscle relaxation in human penile corpus cavernosum. Biochemistry 40, 2678-2688 (2001).
2.Colleluori, D.M., and Ash, D.E. Classical and slow-binding inhibitors of human type II arginase. Biochemistry 40, 9356-9362 (2001).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 193 |
| 分子式 | C5H12BNO4S |
| CAS号 | 63107-40-4 |
| 稳定性 | ≥ 2 years |
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