| 货号 | 89300-1mg |
| 描述 | 8-Hydroxyguanosine is produced by oxidative damage of RNA.1,2 It can be measured in cell digests or in biological fluids as a marker of oxidative stress. When 8-hydroxyguanosine (5-8 mM) is added to Friend erythroleukemia cells, it acts as a growth inhibitor in addition to promoting differentiation.3,4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. The FASEB Journal 4, 2587-2597 (1990). 2.Taddei, F.,Hayakawa, H.,Bouton, M.F., et al. Counteraction by MutT protein of transcriptional errors caused by oxidative damage. Science 278, 128-130 (1997). 3.Mo, Y.,Maki, H. and Sekiguchi, M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein: Sanitization of necleotide pool. Proceedings of the National Academy of Sciences of the United States of America 89, 11021-11025 (1992). 4.Lin, T.S.,Cheng, J.C.,Ishiguro, K., et al. 8-Substituted guanosine and 2-deoxyguanosine derivatives as potential inducers of the differentiation of friend erythroleukemia cells. Journal of Medicinal Chemistry 28, 1194-1198 (1985). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥98% |
| 计算分子量 | 299.2 |
| 分子式 | C10H13N5O6 |
| CAS号 | 3868-31-3 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |