CNX-774
货号：
21475-1mg 基本售价：
392.0 元 规格：
1 mg
产品信息
概述| 货号 | 21475-1mg |
| 描述 | CNX-774 is a potent, selective, and irreversible inhibitor of Bruton’s tyrosine kinase (BTK), an important kinase in the B cell antigen receptor pathway, with IC50 values of <1 nM in biochemical assays and 1-10 nM in cellular assays.1 It inhibits proliferation in HMC-1.1 and HMC-1.2 cells (IC50 = 2.82 and 0.38 µM) but has no effect on cell cycle progression.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Akinleye, A.,Chen, Y.,Mukhi, N., et al. Ibrutinib and novel BTK inhibitors in clinical development. J. Hematol. Oncol. 6(59), (2013).
2.Smilijkovic, D.,Blatt, K.,Stefanzl, G., et al. BTK inhibition is a potent approach to block IgE-mediated histamine release in human basophils. Allergy 1-11 (2017).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 499.5 |
| 分子式 | C26H22FN7O3 |
| CAS号 | 1202759-32-7 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
