FK-506
货号：
10007965-5mg 基本售价：
392.0 元 规格：
5 mg
产品信息
概述| 货号 | 10007965-5mg |
| 描述 | FK-506 is a potent, clinically-useful immunosuppressant in the same molecular class as cyclosporin A and rapamycin.1 Its mechanism of action involves the formation of a high affinity complex (Ki = 0.2 nM) with FK-506 Binding Protein 12 (FKBP12). This complex then inhibits the activity of the calcium/calmodulin-dependent protein phosphatase, calcineurin, leading to disruption of T cell activation.2 The physiological effects of FK-506 also include regulation of nitric oxide neurotoxicity, neurotransmitter release, and regulation of Ca2+releasevia the ryanodine and inositol-(1,4,5)-trisphosphate (IP3) receptors.3 In the latter case, FKBP12 forms a tight complex with both ryanodine and IP3 receptors which can be disrupted by FK-506, thereby rendering the receptors “leaky” to Ca2+. |
| 别名 | Tacrolimus; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Schreiber, S.L. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251(4991), 283-287 (1991).
2.Dumont, F.J. FK506, An immunosuppressant targeting calcineurin function. Current Medicinal Chemistry 7(7), 731-748 (2000).
3.Snyder, S.H.,Sabatini, D.M.,Lai, M.M., et al. Neural actions of immunophilin ligands. Trends in Pharamacological Sciences 19(1), 21-26 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 804 |
| 分子式 | C44H69NO12 |
| CAS号 | 104987-11-3 |
| 稳定性 | ≥ 2 years |
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