CUDA
货号：
10007923-5mg 基本售价：
392.0 元 规格：
5 mg
产品信息
概述| 货号 | 10007923-5mg |
| 描述 | Epoxyeicosatrienoic acid (EpETrE; EET) metabolites of arachidonic acid such as 11(12)-EET and 14(15)-EET have been identified as endothelium derived hyperpolarizing factors with vasodilator activity.1 Soluble epoxide hydrolase (sEH) catalyzes the conversion of EETs to the corresponding dihydroxy eicosatrienoic acids (DiHETrEs; DHETs) thereby diminishing their activity. CUDA is an inhibitor of sEH exhibiting IC50 values of 11.1 nM and 112 nM for the mouse and human enzymes, respectively.2 In COS-7 cells, 10 µM CUDA blocks conversion of 1 µM 14,15-EET to 14,15-DHET by 94%. CUDA activates peroxisome proliferator-activated receptor α (PPARα) 8-fold at a concentration of 10 µM but exhibits no affect on PPARδ or PPARγ3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Fleming, I. Cytochrome P450 epoxygenases as EDHF synthase(s). Pharmacological Research 49, 525-533 (2004).
2.Morisseau, C.,Goodrow, M.H.,Newman, J.W., et al. Structural refinement of inhibitors of urea-based soluble epoxide hydrolases. Biochemical Pharmacology 63, 1599-1608 (2002).
3.Fang, X.,Hu, S.,Watanabe, T., et al. Activation of peroxisome proliferator-activated receptor α by substituted urea-derived soluble epoxide hydrolase inhibitors. Journal of Pharmacology and Experimental Therapeutics 314(1), 260-270 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.5 |
| 分子式 | C19H36N2O3 |
| CAS号 | 479413-68-8 |
| 稳定性 | ≥ 2 years |
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