| 货号 | 70515-5mg |
| 描述 | Inhibition of thromboxane synthase (TXAS), especially in human platelets, has been a clinical objective for many years. 1-Alkyl (N-alkyl)-imidazole derivatives have been recognized as TXAS inhibitors since the early 1980s.1,2,3 Ozagrel is a 1-alkyl imidazole derivative that acts as a selective inhibitor of TXAS with an IC50 of 11 nM. The beneficial effects of TXAS inhibition by ozagrel include improved motor coordination after experimental stroke,4 and antihypertensive effects in spontaneously hypertensive rats.5 |
| 别名 | OKY-046; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Iizuka, K.,Akahane, K.,Momose, D., et al. Highly selective inhibitors of thromboxane synthase. 1. Imidazole derivatives. Journal of Medicinal Chemistry 24, 1139-1148 (1981). 2.Wright, W.B.,Tomcufcik, A.S.,Chan, P.S., et al. Thromboxane synthase inhibitors and antihypertensive agents. 4,N-[(1H-imidazol-1-yl)alkyl] derivatives of quinazoline-2,4(1H,3H)-diones, quinazolin-4(3H)-ones, and 1,2,3-benzotriazin-4(3H)-ones. Journal of Medicinal Chemistry 30, 2277-2283 (1987). 3.Wright, W.B., Jr.,Press, J.B.,Chan, P.S., et al. Thromboxane synthetase inhibitors and antihypertensive agents. 1. N-[(1H-imidazol-1-yl)alkyl]aryl amides and N-[(1H-imidazol-1,2,4-triazol-1-yl)alkyl]aryl amides. Journal of Medicinal Chemistry 29, 523-530 (1986). 4.Ichikawa, K.,Tazawa, S.,Hamano, S., et al. Effect of ozagrel on locomotor and motor coordination after transient cerebral ischemia in experimental animal models. Pharmacology 59, 257-265 (1999). 5.Press, J.B.,Wright, W.B., Jr.,Chan, P.S., et al. Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-Imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents. Journal of Medicinal Chemistry 29(5), 816-819 (1986). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 228.3 |
| 分子式 | C13H12N2O2 |
| CAS号 | 82571-53-7 |
| 稳定性 | ≥ 1 year |
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