ABT-199
货号：
16233-1mg 基本售价：
378.0 元 规格：
1 mg
产品信息
概述| 货号 | 16233-1mg |
| 描述 | B-cell lymphoma/leukemia 2 (Bcl-2) is an anti-apoptotic protein that controls cell survival by binding the BH3 domains of pro-death BAD and BAK proteins and preventing permeabilization of the mitochondrial outer membrane. This protein is tightly regulated for the homeostasis between cell growth and cell death. The gene that encodes this protein is considered an oncogene; its disruption can promote the survival of cancer cells.1 ABT-199 is a BH3 mimetic that selectively inhibits Bcl-2 with subnanomolar affinity (Ki< 0.010 nM), binding over 3 orders of magnitude less avidly to the related family proteins, Bcl-xL and Bcl-W (Kis = 48 and 245 nM, respectively).2 ABT-199 inhibits the growth of Bcl-2-dependent cell lines and in vivo tumor xenografts.2 This compound has shown antileukemic activity in patients with refractory chronic lymphocytic leukemia and holds promise to address additional Bcl-2-dependent cancers.2,3,3 |
| 别名 | GDC 0199; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Davids, M.S. and Letai, A. ABT-199: A new hope for selective BCL-2 inhibition. Cancer Cell 23(2), 139-141 (2013).
2.Souers, A.J.,Leverson, J.D.,Boghaert, E.R., et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nature Medicine 19(2), 202-208 (2013).
3.Tamaki, H.,Harashima, N.,Hiraki, M., et al. Bcl-2 family inhibition sensitizes human prostate cancer cells to docetaxel and promotes unexpected apoptosis under caspase-9 inhibition. Oncotarget (2014).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 868.4 |
| 分子式 | C45H50ClN7O7S |
| CAS号 | 1257044-40-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
