| 货号 | 13143-1mg |
| 描述 | The free fatty acid receptor 1 (FFAR1; GPR40) is highly expressed in pancreatic β-cells and activated by medium and long-chain fatty acids.1 There is evidence of a link between FFAR1 (GPR40) and the ability of fatty acids to amplify glucose-stimulated insulin secretion, making this signaling pathway a potential target for regulating diabetes, obesity, and other metabolic disorders.2,3 CAY10587 is a selective FFAR1 (GPR40) agonist (EC50 = 32 nM) that does not exhibit activity on the related FFARs: FFAR2 (GPR43) or FFAR3 (GPR41).4 At 100 nM, CAY10587 increases glucose-stimulated insulin secretion in the rat insulin-secreting cell line INS-1E.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Briscoe, C.P.,Tadayyon, M.,Andrews, J.L., et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. The Journal of Biological Chemisty 278(13), 11303-11311 (2003). 2.Itoh, Y.,Kawamata, Y.,Harada, M., et al. Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40. Nature 422, 173-176 (2003). 3.Steneberg, P.,Rubins, N.,Bartoov-Shifman, R., et al. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. Cell Metabolism 1, 245-258 (2005). 4.Christiansen, E.,Urban, C.,Merten, N., et al. Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA1/GPR40), a potential target for the treatment of type II diabetes. Journal of Medicinal Chemistry 51, 7061-7064 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.3 |
| 分子式 | C18H16O2 |
| CAS号 | 1082058-99-8 |
| 稳定性 | ≥ 2 years |
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