| 货号 | 11913-1mg |
| 描述 | (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase.1 CYP2C19 metabolizes a variety of therapeutic agents, including omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates.2 Genetic defects in CYP2C19 result in poor metabolism of these compounds, and (S)-mephenytoin can be used to screen for such mutations by assaying its metabolites in urine.2,3,4 (S)-Mephenytoin has anticonvulsant activities.5 |
| 别名 | (S)-5-Ethyl-3-methyl-5-phenylhydantoin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Shimada, T.,Misono, K.S., and Guengerich, F.P. Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. The Journal of Biological Chemisty 261(2), 909-921 (1986). 2.Ferguson, R.J.,de Morais, S.M.,Benhamou, S., et al. A new genetic defect in human CYP2C19: Mutation of the initiation codon is responsible for poor metabolism of S-mephenytoin. Journal of Pharmacology and Experimental Therapeutics 284(1), 356-361 (1998). 3.Ozawa, S.,Soyama, A.,Saeki, M., et al. Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1. Drug Metab.Pharmacokinet. 19(2), 83-95 (2004). 4.Guttendorf, R.J.,Britto, M.,Blouin, R.A., et al. Rapid screening for polymorphisms in dextromethorphan and mephenytoin metabolism. British Journal of Clinical Pharmacology 29(4), 373-380 (1990). 5.Wong, P.T.H.,Tan, S.F., and Lee, H.S. N-demethylation of methyl and dimethyl derivatives of phenytoin and their anticonvulsant activities in mice. Japanese Journal of Pharmacology 48(4), 473-478 (1988). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 218.3 |
| 分子式 | C12H14N2O2 |
| CAS号 | 70989-04-7 |
| 稳定性 | ≥ 2 years |
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