| 货号 | 21802-5mg |
| 描述 | Aminopterin is a synthetic folic acid (Item No. 20515) derivative whose metabolite is a competitive inhibitor of dihydrofolate reductase, which is a cofactor for nucleic acid synthesis. Aminopterin has anticancer and immunosuppressive properties. Formulations containing it have been used for pediatric leukemia though methotrexate (Item No. 13960) is now more commonly used due to a more favorable therapeutic index.1,2,3 Aminopterin is a component of the widely used HAT (hypoxanthine-aminopterin-thymidine) medium to select cells for mammalian cell culture.4 |
| 别名 | 4-amino Folic Acid;4-amino PGA;APGA;NSC 739; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Farber, S.,Diamond, L.K.,Mercer, R.D., et al. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N. Engl. J. Med. 238(23), 787-793 (1948). 2.Goldin, A.,Venditti, J.M.,Humphreys, S.R., et al. A quantitative comparison of the antileukemic effectiveness of two folic acid antagonists in mice. J. Natl. Cancer Inst. 15(6), 1657-1664 (1955). 3.Cole, P.D.,Drachtman, R.A.,Smith, A.K., et al. Phase II trial of oral aminopterin for adults and children with refractory acute leukemia. Clin. Cancer Res. 11(22), 8089-8096 (2005). 4.Littlefield, J.W. Selection of hybrids from matings of fibroblasts in vitro and their presumed recombinants. Science 145(3633), 709-710 (1964). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 440.4 |
| 分子式 | C19H20N8O5 |
| CAS号 | 54-62-6 |
| 稳定性 | ≥ 2 years |
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