CYC-116
货号：
21205-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 21205-1mg |
| 描述 | CYC-116 is a potent Aurora kinase inhibitor exhibiting Ki values of 8.0 and 9.2 nM for Aurora kinases A and B, respectively.1 It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC50 value of 0.54 µM (range = 0.09 – 1.6 µM). It is orally bioavailable and inhibits the growth of human tumor xenografts in mice. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, S.,Midgley, C.A.,Scaërou, F., et al. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J. Med. Chem. 53(11), 4367-4378 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 368.5 |
| 分子式 | C18H20N6OS |
| CAS号 | 693228-63-6 |
| 稳定性 | ≥ 2 years |
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