| 货号 | 21014-1mg |
| 描述 | Levocabastine is a potent and selective histamine H1 receptor antagonist with an IC50 value of 8.32 nM (Kis = 62.5, 23,500, and 1,937 nM for H1, H2, and H3, respectively) for inhibition of phosphoinositide turnover on human conjunctival epithelial cells.1,2 It has been used in clinical formulations in eye drops and nasal sprays for the treatment of allergic conjunctivitis and allergic rhinitis, respectively.3,4 Levocabastine also binds with high affinity to the rat neurotensin-2 receptor with an IC50 value of 10 nM.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yanni, J.M.,Weimer, L.K.,Sharif, N.A., et al. Inhibition of histamine-induced human conjunctival epithelial cell responses by ocular allergy drugs. Arch. Opthalmol. 11795), 643-647 (1999). 2.Sharif, N.A.,Xu, S.X. and Yanni, J.M. Olopatadine (AL-4943A): Ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis. Journal of Ocular Pharmacology and Therapeutics 12(4), 401-407 (1996). 3.Azevedo, M. Topical levocabastine-a review of therapeutic efficacy compared with topical sodium cromoglycate and oral terfenadine on days with high pollen counts. Mediators Inflamm. 4(7), S21-S25 (1995). 4.Mösges, R.,Spaeth, J. and Klimek, L. Efficacy and tolerability of levocabastine and azelastine nasal sprays for the treatment of allergic rhinitis. Mediators Inflamm. 4(7), S11-S15 (1995). 5.Chalon, P.,Vita, N.,Kaghad, M., et al. Molecular cloning of a levocabastine-sensitive neurotensin binding site. FEBS Lett. 386(2-3), 91-94 (1996). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 457 |
| 分子式 | C26H29FN2O2 • HCl |
| CAS号 | 79547-78-7 |
| 稳定性 | ≥ 2 years |
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