| 货号 | 21002-25mg |
| 描述 | (S)-(+)-Clopidogrel is the functional enantiomer of clopidogrel (Item No. 13657), an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).1,2,3,4 Like clopidogrel, (S)-(+)-clopidogrel must be metabolized by cytochrome P450 isoforms to produce an active metabolite.4 |
| 别名 | SR 25990C; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Savi, P.,Labouret, C.,Delesque, N., et al. P2Y12, a new platelet ADP receptor, target of clopidogrel. Biochemical and Biophysical Research Communications 283, 379-383 (2001). 2.von Kügelgen, I. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacology & Therapeutics 110, 415-432 (2006). 3.Nikolic, K.,Ivković, B.,Besović, Z., et al. A validated enantiospecific method for determination and purity assay of clopridogrel. Chirality 21(10), 878-885 (2009). 4.Reist, M.,Roy-de Vos, M.,Montseny, J.-P., et al. Very slow chiral inversion of clopidogrel in rats: A pharmacokinetic and mechanistic investigation. Drug Metab. Dispos. 28(12), 1405-1410 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 419.9 |
| 分子式 | C16H16ClNO2S • H2SO4 |
| CAS号 | 120202-66-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |