Nifekalant (hydrochloride)
货号：
20997-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20997-1mg |
| 描述 | Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials.1 It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 µM).2 Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 µM).3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Huang, Y.,He, Q.,Yang, M., et al. Antiarrhythmia drugs for cardiac arrest: A systemic review and meta-analysis. Crit. Care 17(4), R173 (2013).
2.Du, L.P.,Tsai, K.C.,Li, M.Y., et al. The pharmacophore hypotheses of IKr potassium channel blockers: Novel class III antiarrhythmic agents. Bioorg. Med. Chem. Lett. 14(18), 4771-4777 (2004).
3.Wittwer, M.B.,Zur, A.A.,Khuri, N., et al. Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling. J. Med. Chem. 56(3), 781-795 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 441.9 |
| 分子式 | C19H27N5O5 • HCl |
| CAS号 | 130656-51-8 |
| 稳定性 | ≥ 2 years |
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