| 货号 | 20951-1mg |
| 描述 | Atorvastatin lactone is a prodrug form of atorvastatin (Item No. 10493), an HMG-CoA reductase inhibitor used to lower blood cholesterol levels.1 The lactone hydrolyzes rapidly to the acid form of atorvastatin in human serum at room temperature.2 Atorvastatin lactone can also be formed in vivo from atorvastatin by certain uridine 5’-diphospho-glucuronosyltransferases.3 Like atorvastatin, the lactone inhibits P-glycoprotein in a concentration-dependent manner.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ishigami, M.,Honda, T.,Takasaki, W., et al. A comparison of the effects of 3-hydroxy-3-methylglutaryl-coenzyme a (HMG-CoA) reductase inhibitors on the CYP3A4-dependent oxidation of mexazolam in vitro. Drug Metab. Dispos. 29(3), 282-288 (2001). 2.Jemal, M.,Ouyang, Z.,Chen, B.C., et al. Quantitation of the acid and lactone forms of atorvastatin and its biotransformation products in human serum by high-performance liquid chromatography with electrospray tandem mass spectrometry. Rapid Commun Mass Spectrom. 13(11), 1003-1015 (1999). 3.Schirris, T.J.J.,Ritschel, T.,Bilos, A., et al. Statin lactonization by uridine 5-diphospho-glucuronosyltransferases (UGTs). Mol. Pharm. 12(11), 4048-4055 (2015). 4.Bogman, K.,Peyer, A.-K.,Török, M., et al. HMG-CoA reductase inhibitors and P-glycoprotein modulation. Br. J. Pharmacol. 132(6), 1183-1192 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 540.6 |
| 分子式 | C33H33FN2O4 |
| CAS号 | 125995-03-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |