AZD 1208
货号：
20235-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20235-1mg |
| 描述 | AZD 1208 is a potent, selective, and orally available inhibitor of all three forms of the proto-oncogene Pim kinase (IC50s = 0.4, 5.0, and 1.9 nM for Pim-1, Pim-2, and Pim-3, respectively).1 It causes cell cycle arrest and apoptosis in MOLM-16 megakaryoblastic leukemia cells and inhibits the growth of MOLM-16 xenograft tumors in mice.1 It has efficacy against acute myeloid leukemia and glioblastoma cells when combined with mTOR and p110α inhibitors, respectively.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Keeton, E.K.,McEachern, K.,Dillman, K.S., et al. AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia. Blood 123(6), 905-913 (2014).
2.Harada, M.,Benito, J.,Yamamaoto, S., et al. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression. Oncotarget 6(35), 37930-37947 (2015).
3.Iqbal, A.,Eckerdt, F.,Bell, J., et al. Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition. Oncotarget 7(22), 33192-33201 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 379.5 |
| 分子式 | C21H21N3O2S |
| CAS号 | 1204144-28-4 |
| 稳定性 | ≥ 2 years |
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