SU 4312
货号：
20213-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20213-1mg |
| 描述 | SU 4312 is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50s = 0.8 and 19.4 μM, respectively).1 It demonstrates IC50 values >100 μM at EGFR, HER2, and IGF-1R.1 SU 4312 has been shown to inhibit VEGF-dependent angiogenesis in a zebrafish assay (IC50 = 1.8 µM) without affecting normal cells.2 SU 4312 has also been shown to prevent MPP+-induced neuronal apoptosis in vitro, as well as to decrease MPTP-induced loss of dopaminergic neurons, reduce expression of mRNA for tyrosine hydroxylase, and impair swimming behavior in zebrafish.3 |
| 别名 | NSC 86429; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sun, L.,Tran, N.,Tang, F., et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 41(14), 2588-2603 (1998).
2.Tran, T.C.,Sneed, B.,Haider, J., et al. Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish. Cancer Res. 67(23), 11386-11392 (2007).
3.Cui, W.,Zhang, Z.,Li, W., et al. The anti-cancer agent SU4312 unexpectedly protects against MPP+ -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Br.J.Pharmacol. 168(5), 1201-1214 (2013).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 264.3 |
| 分子式 | C17H16N2O |
| CAS号 | 1429018 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
