NSC 12
货号：
20117-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20117-1mg |
| 描述 | NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs).1 NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 µM, preventing them from forming HSPG/FGF/FGFR ternary complexes.1 NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice.1 |
| 别名 | NSC 172285; |
性能| 供应商 | Cayman |
| 应用文献 |
1.ROnca, R.,Giacomini, A.,Di Salle, E., et al. Long-pentraxin 3 derivative as a small-molecule FGF trap for cancer therapy. Cancer Cell 28(2), 225-238 (2015).
|
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 484.5 |
| 分子式 | C24H34F6O3 |
| CAS号 | 102586-30-1 |
| 稳定性 | ≥ 2 years |
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