HG-10-102-01
货号：
20049-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 20049-1mg |
| 描述 | HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM).1 It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively).1 HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Choi, H.G.,Zhang, J.,Deng, X., et al. Brain Penetrant LRRK2 Inhibitor. ACS Med. Chem. Lett. 3(8), 658-662 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 377.8 |
| 分子式 | C17H20ClN5O3 |
| CAS号 | 1351758-81-0 |
| 稳定性 | ≥ 2 years |
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