CPTH6 (hydrobromide)
货号：
19828-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19828-1mg |
| 描述 | CPTH6 is a thiazole derivative that inhibits the lysine acetyltransferase activity of Gcn5 and pCAF but not p300 or CBP.1 It blocks the acetylation of H3/H4 histones and α-tubulin in several leukemia cell lines.1 CPTH6 reduces cell viability, arresting cell cycling in the G0/G1 phase and inducing apoptosis.1 It impairs autophagy in a variety of tumor cell lines, at least in part by altering ATG7-mediated elongation of autophagosomal membranes.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Trisciuoglio, D.,Ragazzoni, Y.,Pelosi, A., et al. CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells. Clin. Cancer Res. 18(2), 475-486 (2012).
2.Ragazzoni, Y.,Desideri, M.,Gabellini, C., et al. The thiazole derivative CPTH6 impairs autophagy. Cell Death Dis. 4, e524 (2013).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 386.7 |
| 分子式 | C15H16ClN3S • HBr |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
