ETP-46464
货号：
19809-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19809-1mg |
| 描述 | ETP-46464 is an inhibitor of the DNA damage response kinase Ataxia-telangiectasia mutated (ATM)- and Rad3-related (ATR) with an IC50 value of 25 nM.1 It also inhibits mTOR and DNA-dependent protein kinase (IC50s = 0.6 and 36 nM, respectively), and is moderately active against PI3Kα and ATM (IC50s = 170 and 545 nM, respectively).1 Pharmacological inhibition of ATR is reported to generate replicative stress, leading to chromosomal breakage in the presence of conditions that stall replication forks.1 ETP-46464 has been shown to be toxic to p53-deficient cells, which is exacerbated by replicative stress-generating conditions such as the overexpression of cyclin E.1 |
| 别名 | ATM Inhibitor III;ATR Inhibitor III; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Toledo, L.I.,Murga, M.,Zur, R., et al. A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations. Nat.Struct.Mol.Biol. 18(6), 721-727 (2011).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 470.5 |
| 分子式 | C30H22N4O2 |
| CAS号 | 1345675-02-6 |
| 稳定性 | ≥ 2 years |
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