NCT-502
货号：
19716-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 19716-1mg |
| 描述 | NCT-502 is an inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), inhibiting serine synthesis from 3-phosphoglycerate in cells with an IC50 value of 3.7 µM.1 It is inactive against a panel of other dehydrogenases and shows minimal cross reactivity with G protein-coupled receptors. NCT-502 reversibly blocks the production of glucose-derived serine in cells and displays reasonable in vitro absorption, distribution, metabolism, and excretion.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pacold, M.E.,Brimacombe, K.R.,Chan, S.H., et al. A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate. Nature Chemical Biology 12(6), 452-458 (2016).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 395.4 |
| 分子式 | C18H20F3N5S |
| CAS号 | 1542213-00-2 |
| 稳定性 | ≥ 1 year |
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