| 货号 | 19648-50mg |
| 描述 | Cepharanthine is a biscoclaurine alkaloid extracted from S. cepharantha that is cationic and amphipathic and has been reported to decrease the fluidity of biological membranes.1 It exhibits antiparasitic, antimalarial, antiviral, anti-inflammatory, antimetastatic, and anticancer activities in various cell and animal models.1,2,3 Cepharanthine can decrease LPS-stimulated expression of TNF-α, IL-6, and IL-1β in macrophages and prevent the activation of NF-κB, ERK, JNK, and p38 MAPK.4 It has also been shown to inhibit cell and tumor growth, inducing G1 phase cell cycle arrest and apoptosis, and decreasing expression of STAT3, Bcl-xL, c-Myc, and cyclin D1 in osteosarcoma models.5 |
| 别名 | O-Methylcepharanoline;NSC 623442; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Matsuda, K.,Hattori, S.,Komizu, Y., et al. Cepharanthine inhibited HIV-1 cell-cell transmission and cell-free infection via modification of cell membrane fluidity. Bioorganic & Medicinal Chemistry Letters 24(9), 2115-2117 (2014). 2.Desgrouas, C.,Chapus, C.,Desplans, J., et al. In vitro antiplasmodial activity of cepharanthine. Malar.J. 13:327, (2014). 3.Rogosnitzky, M., and Danks, R. Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions. Pharmacological Reports 63(2), 337-347 (2011). 4.Huang, H.,Hu, G.,Wang, C., et al. Cepharanthine, an alkaloid from Stephania cepharantha Hayata, inhibits the inflammatory response in the RAW264.7 cell and mouse models. Inflammation 37(1), 235-246 (2014). 5.Chen, Z.,Huang, C.,Yang, Y.l., et al. Inhibition of the STAT3 signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells. Acta.Pharmacol.Sin. 33(1), 101-108 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 606.7 |
| 分子式 | C37H38N2O6 |
| CAS号 | 481-49-2 |
| 稳定性 | ≥ 2 years |
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