| 货号 | 19642-1mg |
| 描述 | NE 100 is a potent antagonist of sigma-1 (σ1) receptors (IC50 = 4.16 nM).1,2,3 It only weakly antagonizes dopamine, serotonin, and PCP receptors, but may indirectly alter receptor activity through its effects on σ1.1,2,3 NE 100 is commonly used to study the role of σ1 receptor signaling in cells or animals.4,5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chaki, S.,Tanaka, M.,Muramatsu, M., et al. NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain. Eur. J. Pharmacol. 251(1), R1-2 (1994). 2.Okuyama, S.,Imagawa, Y.,Ogawa, S., et al. NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci. 53(18), PL285-PL290 (1993). 3.Yamamoto, H.,Yamamoto, T.,Sagi, N., et al. NE-100, a novel sigma ligand: Effects on [3H]TCP binding to intact primary cultured neuronal cells. Life Sci. 56(2), PL39-PL43 (1995). 4.Dalwadi, D.A.,Kim, S., and Schetz, J.A. Activation of the sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astroglia. Neurochem Int. 105(5), 27-31 (2017). 5.Hong, J.,Sha, S.,Zhou, L., et al. Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons. Cell Death Dis. 6, e1832 (2015). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 392 |
| 分子式 | C23H33NO2 • HCl |
| CAS号 | 149409-57-4 |
| 稳定性 | ≥ 2 years |
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